Letter. Long-term prophylaxis and immune parameters in haemophilia

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Prophylaxis in people with haemophilia.

A four-decade clinical experience and recent evidence from randomised controlled studies definitively recognised primary prophylaxis, i.e. the regular infusion of factor concentrates started after the first haemarthrosis and/or before the age of two years, as the first-choice treatment in children with severe haemophilia. The available data clearly show that preventing bleeding since an early a...

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Prophylactic treatment of haemophilia has been gaining acceptance as the optimal therapeutic option in an increasing number of haemophilia centres in the developed world in recent years. This paper focus on three aspects of prophylactic therapy: when to start treatment, venous access and the dose/dose interval. Evidence is in favour of prophylactic treatment to be started at an early age using ...

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ژورنال

عنوان ژورنال: Journal of Tropical Pediatrics

سال: 1999

ISSN: 0142-6338,1465-3664

DOI: 10.1093/tropej/45.2.122